Chapter 83 Skin, Soft tissue and Acute Osteomyelitis Q&A (1 of 29) Sample Questions
1. A patient is confirmed to have osteomyelitis. Doctor plans on starting Vancomycin orally for the patient. Which of the following is true?
- A. Vancomycin is the best if given orally.
- B. Oral vancomycin is not absorbed.
- C. It is not the drug of choice against MRSA osteomyelitis.
- D. None of the above.
Ans:
B
Tips: Oral vancomycin is only used for P. colitis treatment. Otherwise, in all other infections, Vancomycin is used injection.
Absorption: Oral vancomycin is poorly absorbed from the GI tract. Intramuscular absorption is erratic. Intraperitoneal administration results in approximately 38% systemic absorption.
Distribution: The volume of distribution of vancomycin is 0.4–1 L/kg and the α-distribution phase ranges from 30 minutes to 1 hour. Vancomycin is 50–55% protein bound. The drug distributes widely into body tissue and fluids including pericardial, pleural, ascitic and synovial fluid. Low and variable vancomycin concentrations are obtained in CSF; however, inflammation increases CSF penetration and concentrations may be higher here in patients with meningitis. Penetration into skin and lung tissue has been found to be variable
Absorption: Oral vancomycin is poorly absorbed from the GI tract. Intramuscular absorption is erratic. Intraperitoneal administration results in approximately 38% systemic absorption.
Distribution: The volume of distribution of vancomycin is 0.4–1 L/kg and the α-distribution phase ranges from 30 minutes to 1 hour. Vancomycin is 50–55% protein bound. The drug distributes widely into body tissue and fluids including pericardial, pleural, ascitic and synovial fluid. Low and variable vancomycin concentrations are obtained in CSF; however, inflammation increases CSF penetration and concentrations may be higher here in patients with meningitis. Penetration into skin and lung tissue has been found to be variable