Chapter 12. Pharmacokinetics (1 of 67) Sample Questions

1. A patient with COPD is using salbutamol, tiotropium, salmeterol and theophylline. He is a smoker and drinks alcohol daily. Recently, he quit smoking. What should concern the pharmacist?
  1. A. May increase risk of theophylline toxicity
  2. B. theophylline serum levels can lower than effective dose
  3. C. Theophylline serum levels will not change
  4. D. Patient should not quit smoking when using theophylline
Ans: A
Tips: smoking increased clearance of theophylline, so quitting smoking can decrease clearance and increase theophylline serum levels. (>20 mg/L)